Motivation: The ToxCast database is a valuable resource for computational toxicology and new approach methodologies (NAMs), but the approximately 100GB MySQL distribution is difficult to use for…
Pig vocalizations convey information about the emotional states of individuals, varying with arousal and valence. Studies show that different call types reflect distinct emotional contexts and social…
Cyclin-dependent kinases CDK12 and CDK13 are RNA polymerase II C-terminal domain Ser2 kinases that regulate transcriptional elongation and co-transcriptional RNA processing. Loss-of-function (LOF)…
The rapid explosion of large-scale, high-throughput biological data has created an urgent demand for efficient analysis pipelines. Traditional bioinformatics approaches, while powerful, often require…
NRF1 is a key mediator of the proteasome recovery pathway, yet its regulation by ER-resident factors is not fully elucidated. Here, we demonstrate that selenoproteins SELS and SELK are critical…
In compositional next-generation sequencing (NGS) analyses (including microbiome studies, RNA-seq and metagenomics) the arithmetic mean (AM) of relative proportions is the default operator for…
cadmus is an open-source Python toolkit for automated retrieval and processing of full-text biomedical literature. It utilises programmatic access to PubMed, Crossref, Europe PMC, PMC, and publisher…
A common approach for investigating high-level visual cortex with functional magnetic resonance imaging (fMRI) is to define regions of interest (ROIs) in individual participants using functional…
When hearing fails, stimulation of the auditory nerve by electrical cochlear implants (eCIs) partially restores hearing, with most eCI users achieving open speech understanding. However, the broad…
Hydroxychloroquine (HCQ), a clinically relevant quinoline derivative, impairs both collective and individual cell migration by disrupting actin and vimentin cytoskeletal dynamics during wound…