Interdisciplinary

CRISPR-based sensor detects DNA at record-low concentrations without amplification

Proceedings of the National Academy of Sciences, Volume 123, Issue 21, May 2026. <br/>SignificanceAmplification-free CRISPR diagnostics are often described as simple positive feedback circuits, yet background noise signal from target-independent activation can be undesirably high. Existing approaches treat these background “leakage” …

Source: Amplification-free dual-blocking autocatalytic CRISPR-Cascade for attomolar DNA detection with low nonspecific signal