Chemistry

[ASAP] Conformationally Switchable Molecular Trefoil Knot Assembled From 2,6-Bis(1,2,3-triazol-4-yl)pyridine (btp) Building Blocks

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Researchers synthesized a molecular trefoil knot using 2,6-bis(1,2,3-triazol-4-yl)pyridine (btp) building blocks through metal-directed self-assembly. The resulting knot exhibits conformational switching behavior, meaning it can adopt distinct geometric configurations in response to external stimuli. This work demonstrates that btp ligands serve as effective components for constructing topologically complex interlocked architectures with dynamic properties.


Conformationally switchable molecular knots represent a foundational step toward functional molecular machines and responsive materials, with potential applications in controlled drug delivery, molecular computing, and the design of advanced nanoscale devices.


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Journal of the American Chemical Society
DOI: 10.1021/jacs.6c07733

Source: [ASAP] Conformationally Switchable Molecular Trefoil Knot Assembled From 2,6-Bis(1,2,3-triazol-4-yl)pyridine (btp) Building Blocks