Chemistry

Bacteria Transform Peptide Molecule to Perform Completely New Function

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Researchers have discovered that Pandoraea bacteria produce molecules called pandorachelins through a molecular remodeling process. These bacteria take existing peptide structures and chemically modify them to create new molecules with different functions, similar to how buildings are renovated and repurposed. This represents a novel example of how microorganisms can repurpose molecular building blocks through enzymatic modifications.


Understanding how bacteria remodel peptides could lead to new approaches in drug development and biotechnology, as these modification processes might be harnessed to create novel therapeutic compounds or industrial chemicals with specific desired properties.


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Remodeling may bring to mind construction crews and scaffolding, but the process is far from unique to buildings. Even molecules can be remodeled. Pandorachelins, newly discovered molecules produced by Pandoraea bacteria, are one example.

Source: Molecular switch-up: Bacteria remodel a peptide to take on new role