Chemistry

Biomolecular condensates reveal surprising activity as catalysts

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Biomolecular condensates are membraneless structures found throughout living cells, from bacteria to mammals, composed of DNA, RNA, and proteins. These molecular communities serve as cellular hubs where various molecules gather to coordinate biochemical reactions. Recent findings demonstrate that these condensates possess catalytic activity, challenging previous understanding of their primarily organizational role in cells.


Understanding the catalytic function of biomolecular condensates could revolutionize our comprehension of cellular metabolism and disease mechanisms. This knowledge may lead to new therapeutic approaches for conditions involving dysfunctional condensates, such as neurodegenerative diseases and certain cancers.


Biomolecular condensates are ubiquitous in living cells, including bacteria, viruses, plants and mammalian systems. These membraneless bodies, or molecular communities made up of DNA, RNA and proteins, are where molecules large and small within the cell come together to coordinate various biochemical reactions.

Source: Biomolecular condensates reveal surprising activity as catalysts