Interdisciplinary

Bones release proteins that may slow aging and extend lifespan

How the science connects

Exercise physiologyCellular senescenceEndocrinology

AI Insight

Research in mice has demonstrated that exercise stimulates bone cells called osteocytes to release antiaging proteins. These secreted chemicals appear to slow the aging process and may contribute to increased lifespan. The findings suggest bones play a previously unrecognized role in systemic aging beyond their structural function.


This discovery could lead to new therapeutic approaches for age-related conditions by targeting bone-derived proteins. Understanding this mechanism may help develop interventions that mimic the antiaging benefits of exercise for people unable to maintain regular physical activity.


Exercise triggers bone cells called osteocytes to secrete antiaging chemicals in mice

Source: Bones may release proteins that slow aging and extend life span