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Brain scans show why long COVID causes fatigue and brain fog

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Researchers have identified potential brain damage in dopamine-releasing neurons as a possible mechanism underlying long COVID symptoms. The study used brain imaging to demonstrate that patients with long COVID may experience neurological changes affecting dopamine pathways, which could explain common symptoms including persistent fatigue, reduced motivation, slowed physical movement, and cognitive impairments such as brain fog and memory problems. This neurobiological finding suggests that long COVID may have direct effects on specific brain circuits rather than being solely a post-viral syndrome.


This discovery could redirect treatment approaches for long COVID toward therapies that specifically target the dopamine system, potentially offering relief for millions of patients worldwide suffering from debilitating neurological symptoms. Understanding the biological basis of these symptoms may also help validate patient experiences and guide the development of diagnostic tools for long COVID.


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Researchers have found evidence that long COVID may damage dopamine releasing neurons in the brain, potentially explaining persistent fatigue, low motivation, slowed movement, and memory difficulties. The discovery could lead to new treatments that target the brain’s dopamine system.

Source: Brain scans reveal a possible cause of long COVID fatigue and brain fog