Medicine

Global Health Faces Unprecedented Threats in the 21st Century

How the science connects

Climate changeEpidemiologyGlobal health

AI Insight

The Lancet Commission on 21st century global health threats presents a framework for identifying and prioritizing major health risks through the end of this century. The report argues that recent global crises including COVID-19, Ebola outbreaks, geopolitical conflicts, climate change acceleration, and the rise of artificial intelligence demonstrate the vulnerability of existing health systems and assumptions about stability. The commission advocates for systematic, repeatable risk assessment and preparedness planning by governments and multilateral institutions to counter short-term and localized approaches to global health threats.


This commission provides a strategic framework for policymakers and health organizations to anticipate and prepare for future health emergencies rather than merely reacting to them. The approach addresses the inadequacy of current short-term planning in the face of interconnected global threats that can rapidly destabilize health systems worldwide.


This report from the Lancet Commission on 21st century global threats to health lays out a foresight-driven, health-focused approach to identifying and prioritising major threats to global health over the remainder of the century. We argue that recent global shocks (including COVID-19, Ebola Bundibugyo virus disease, major geopolitical conflict, accelerating climate impacts, rapid shifts in development assistance, and the emergence of powerful artificial intelligence [AI] systems) show how quickly assumptions about stability can be overturned—and why governments and multilateral institutions must counter short-termism and localism with systematic, repeatable risk assessment and preparedness planning.

Source: [The Lancet Commissions] The Lancet Commission on 21st century global threats to health