Medicine

Leucovorin Dispensing to U.S. Children in 2025

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This article examines leucovorin dispensing patterns to pediatric patients in the United States during 2025. Leucovorin, also known as folinic acid, is commonly used as a rescue agent following high-dose methotrexate chemotherapy and in the treatment of folate deficiency. The study analyzes prescription trends, dosing patterns, and demographic distribution of leucovorin use among children across different healthcare settings.


Understanding leucovorin dispensing patterns helps optimize pediatric cancer treatment protocols and ensures appropriate medication access for children requiring folate rescue therapy. This data can inform healthcare policy, drug supply chain management, and identify potential disparities in access to essential supportive cancer care medications.


New England Journal of Medicine, Volume 395, Issue 7, Page 719-721, August 13, 2026.

Source: Leucovorin Dispensing to U.S. Children in 2025