Chemistry

Lichen compounds show promise as natural anti-inflammatory treatments

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This study used high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC-QTOF-MS/MS) to analyze the chemical composition of lichen extracts and identify specific metabolites responsible for anti-inflammatory properties. Through chemometric analysis, researchers established correlations between particular lichen-derived compounds and their ability to reduce inflammation. The metabolomic profiling approach enabled the identification of bioactive molecules that could explain the traditional medicinal uses of lichens.


The identification of specific anti-inflammatory compounds in lichens could lead to the development of new natural therapeutic agents for treating inflammatory diseases. This methodology also provides a systematic approach for discovering bioactive compounds in other understudied organisms, potentially accelerating natural product drug discovery.


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Source: HPLC-QTOF-MS/MS-based metabolomic profiling combined with chemometric analysis links lichen metabolites to anti-inflammatory activity