Chemistry

New dual-sensor detects Vitamin C quality in pharmaceutical products

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Researchers developed a fluorescence-based sensing method to detect ascorbic acid (vitamin C) using carbon quantum dots and rhodamine 6G dye modulated by iron ions (Fe3+). The system exhibits an "on-off-on" fluorescence response where ascorbic acid restores fluorescence that was initially quenched by Fe3+, enabling quantitative detection. This dual-emission approach demonstrates high sensitivity and selectivity for ascorbic acid detection in pharmaceutical samples.


This method provides a practical tool for quality control in pharmaceutical manufacturing, allowing rapid and accurate measurement of vitamin C content in medications and supplements. The technique could improve safety and consistency in drug production while offering a cost-effective alternative to traditional analytical methods.


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Source: “On–off-on” fluorescence sensing of ascorbic acid based on a Fe3+-modulated carbon quantum dots–rhodamine 6G dual-emission system: application to pharmaceutical quality control