Medicine

New psychedelic candidate may spare the gut while still healing the brain

How the science connects

DepressionPsychedelic therapyNeuropharmacology

AI Insight

Researchers are investigating psychedelic drugs as potential treatments for mental health conditions such as depression, with evidence suggesting they may work faster and require fewer doses than conventional antidepressants. Current psychedelic therapies face challenges due to off-target effects that produce unwanted side effects. Scientists are now working to develop new psychedelic candidates that could maintain therapeutic benefits for the brain while minimizing adverse effects on other body systems like the gut.


If successful, refined psychedelic compounds could offer more tolerable and practical treatment options for patients with depression and other mental health disorders who may not respond well to traditional medications. This could expand access to psychedelic-assisted therapy by reducing the burden of side effects that currently limit their clinical use.


Psychedelic drugs are best known for altering perception and producing vivid hallucinations, but scientists are increasingly interested in what else they might do. A growing body of research suggests that these mind-altering substances could hold real promise as treatments for mental health conditions like depression, acting faster and requiring far fewer doses than standard antidepressants. Despite their promise, today’s psychedelic treatments are often hampered by off-target effects that can cause unwanted side effects.

Source: New psychedelic candidate may spare the gut while still healing the brain