AI Insight
This editorial introduces a collection of articles that advocates for a broader approach to neurodegeneration research. Rather than focusing narrowly on individual diseases, specific cell types, or isolated mechanisms, the collection emphasizes studying neurodegeneration within its complete physiological context. The approach examines not only diseased neurons but also the surrounding tissue microenvironment and its interactions.
Why it matters
Understanding neurodegeneration in its full physiological context could lead to more effective therapeutic strategies by identifying targets beyond neurons themselves. This holistic perspective may reveal common mechanisms across different neurodegenerative diseases and uncover how the tissue microenvironment contributes to disease progression.
Understand the Science
by Joanna Clarke, Sarah Jäkel
Research into neurodegeneration is often confined to a single disease, cell type or mechanism. A new collection of articles explores neurodegeneration within its physiological context, looking beyond diseased neurons to the surrounding tissue microenvironment.
Research into neurodegeneration is often confined to a single disease, cell type or mechanism. This Editorial highlights a new collection of articles that explore neurodegeneration within its physiological context, looking beyond diseased neurons to the surrounding tissue microenvironment.
Source: Rethinking neurodegeneration: Placing disease in its physiological context