AI Insight
This is a correction notice published in PLOS ONE regarding a previously published protocol article. The original article described a methodology for using human genetic data to identify changes in circulating protein levels that result from cancer processes rather than causing them. The correction addresses errors or omissions in the original protocol publication, though the specific nature of the corrections is not detailed in the provided excerpt.
Why it matters
Understanding which protein level changes are consequences rather than causes of cancer is important for distinguishing true therapeutic targets from mere biomarkers. This methodological protocol could help researchers avoid pursuing drug targets that would not effectively prevent or treat cancer.
Understand the Science
by Lisa M. Hobson, Richard M. Martin, Karl Smith-Byrne, George Davey Smith, Gibran Hemani, Joseph H. Gilbody, James Yarmolinsky, Sarah E. R. Bailey, Lucy J. Goudswaard, Philip C. Haycock