AI Insight
Scientists are developing pharmaceutical drugs engineered to remain active in the body for extended periods ranging from months to years, rather than requiring daily or frequent administration. These long-acting medications utilize advanced delivery systems and formulations that allow therapeutic compounds to be released slowly over time from a single dose. The technology has particular relevance for treating chronic conditions and preventing diseases that currently require regular medication adherence.
Why it matters
Extended-release drugs could dramatically improve treatment outcomes in low- and middle-income countries where access to healthcare facilities is limited and medication adherence is challenging. This approach may transform management of conditions like HIV prevention, contraception, and chronic diseases by eliminating the need for frequent dosing and reducing the burden on healthcare infrastructure.
Understand the Science
Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02660-9
Medication that persists inside the body for months or years could transform the treatment and prevention of many conditions — especially in low- and middle-income countries.
Source: Dose once, treat forever: drugs are being engineered to last much longer