AI Insight
Researchers have developed CIRPIN, a systematic method to identify circular permutations across the protein universe. Circular permutations are proteins that fold into similar three-dimensional structures despite having different locations of their N- and C-termini, representing an important but previously difficult-to-detect evolutionary phenomenon. This comprehensive mapping reveals widespread occurrence of these structural rearrangements that can generate new biological functions while maintaining protein architecture.
Why it matters
Understanding circular permutations provides insights into protein evolution and how nature creates functional diversity from existing protein folds. This systematic approach could aid in protein engineering and drug design by revealing how structural rearrangements create novel biochemical activities.
Understand the Science
Proceedings of the National Academy of Sciences, Volume 123, Issue 36, September 2026. <br/>SignificanceCircular permutation—a phenomenon where proteins fold into a similar 3D shape, yet differ in their termini positioning—presents a fascinating evolutionary puzzle. However, identifying such relationships has remained challenging due to search …
Source: Systematic discovery of circular permutations across the protein universe using CIRPIN