Chemistry

[ASAP] Piecewise Stereoselective Assembly of Multisubstituted Alkenes

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This research presents a new synthetic method for constructing multisubstituted alkenes with precise control over stereochemistry using a piecewise assembly approach. The technique allows chemists to selectively build complex carbon-carbon double bonds with multiple substituents while controlling the spatial arrangement of atoms around the double bond. The method addresses a longstanding challenge in organic synthesis by enabling modular construction of these important molecular structures.


Multisubstituted alkenes are common structural motifs in pharmaceuticals, natural products, and advanced materials. This stereoselective synthetic method provides chemists with better tools to create these molecules efficiently, potentially accelerating drug discovery and the development of new functional materials.


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Journal of the American Chemical Society
DOI: 10.1021/jacs.6c09135

Source: [ASAP] Piecewise Stereoselective Assembly of Multisubstituted Alkenes