This study aims to investigate the cardioprotective effects of 4-Hydroxybenzaldehyde (4-HBA) against isoproterenol (ISO)-induced cardiac fibrosis and to elucidate the underlying mechanisms. In vivo,…
Control of gene expression by transcription factors (TFs) is a critical mechanism for cells to maintain homeostasis in response to environmental signals. Gene network models that predict regulatory…
Targeted protein degradation (TPD) offers a route to eliminate disease-driving proteins that remain inaccessible to conventional inhibitors. However, degrader discovery remains low-throughput,…
N-linked glycosylation is known to modulate the catalytic function of human carbonic anhydrase (HCA) IX, yet its influence on the underlying free-energy landscape remains largely unexplored. In the…
Excitatory (E) and inhibitory (I) neural populations interact within and across distributed regions to support brain function, yet local and distributed E and I dynamics during naturalistic behavior…
The dorsal cochlear nucleus (DCN) is a cerebellum-like structure in the mammalian auditory brainstem that combines auditory nerve input with diverse auditory and non-auditory signals conveyed by…
A 30-year conservation effort has helped the critically endangered Galápagos snapdragon (Galvezia leucantha subsp. leucantha) recover from just six individuals to a small, carefully tended wild…
University of Oregon biologists have resurrected prehistoric proteins up to 160 million years old that carry natural antimicrobial properties. The revived molecules could inspire the design of new…
Moving threatened sea turtle nests to cooler, safer parts of the beach can save entire clutches from rising tides and extreme heat, but new research suggests it may have hidden consequences for the…
Opportunities to directly observe how life colonizes newly formed land and how ecosystems subsequently develop are exceedingly rare. In a study published in the Journal of Plant Research, researchers…