In reinforcement learning, an agent learns to map representations of the environment state to predictions of future reward. Most prior work in neuroscience has assumed a fixed representation and…
The RNA helicase MOV10 is highly expressed in developing brain, is present in synapses and is required for embryonic viability. A murine brain-specific knockout of MOV10 (Mov10 Deletion) has a…
Parkinsons disease (PD) is associated with motor impairment and cortical synaptic dysfunction, which involve altered glutamate receptor trafficking, yet the underlying mechanisms remain incompletely…
Motivation: The ToxCast database is a valuable resource for computational toxicology and new approach methodologies (NAMs), but the approximately 100GB MySQL distribution is difficult to use for…
Pig vocalizations convey information about the emotional states of individuals, varying with arousal and valence. Studies show that different call types reflect distinct emotional contexts and social…
Cyclin-dependent kinases CDK12 and CDK13 are RNA polymerase II C-terminal domain Ser2 kinases that regulate transcriptional elongation and co-transcriptional RNA processing. Loss-of-function (LOF)…
The rapid explosion of large-scale, high-throughput biological data has created an urgent demand for efficient analysis pipelines. Traditional bioinformatics approaches, while powerful, often require…
NRF1 is a key mediator of the proteasome recovery pathway, yet its regulation by ER-resident factors is not fully elucidated. Here, we demonstrate that selenoproteins SELS and SELK are critical…
In compositional next-generation sequencing (NGS) analyses (including microbiome studies, RNA-seq and metagenomics) the arithmetic mean (AM) of relative proportions is the default operator for…
cadmus is an open-source Python toolkit for automated retrieval and processing of full-text biomedical literature. It utilises programmatic access to PubMed, Crossref, Europe PMC, PMC, and publisher…