Experimental RNA drug slashes harmful cholesterol levels in early human trial
A single dose of Kylo-11 was well tolerated, and at doses of 225 mg or higher, durably reduced serum lipoprotein(a) concentrations up to 48 weeks.
Medicine
New RNA therapy dramatically lowers dangerous cholesterol protein long-term
Lipoprotein(a) is causally associated with an increased risk of atherosclerotic cardiovascular disease and calcific aortic valve stenosis.1 Clinical trials of proprotein convertase subtilisin/kexin…
Experimental eye drops help blind mice see again
Scientists have created light-activated drugs that helped blind mice perceive light again and restored visually guided behavior without gene therapy, implants, or specialized lighting. Even more…
A common vape flavoring may disrupt early embryo development
A popular vanilla flavoring in e-cigarettes may interfere with some of the earliest steps of human development. In lab experiments, vanillin caused embryonic stem cells to lose their ability to…
Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy
New England Journal of Medicine, Ahead of Print. <br/>
Scientists tested 212 plant-based meat alternatives. Every one contained fungal toxins
Every one of 212 plant-based meat alternatives and drinks tested in the UK contained at least one naturally occurring fungal toxin, though concentrations remained below recommended EU guideline…
Digital pets motivate people to move 20% more each day
According to a master’s thesis at the Norwegian University of Science and Technology (NTNU), a mobile game can make physical activity more enjoyable. Two master’s students investigated how the mobile…
Wildlife Farmers in Vietnam Face Dangerous Hantavirus Exposure Risk
Wildlife farming is common in Vietnam, where people breed and trade wild animals for pets, food and traditional medicine.
Genetic Links to Brain Waves Reveal Alzheimer’s Disease Risk Factors
The mild cognitive impairment (MCI) continuum represents a critical stage in the Alzheimer’s disease (AD), yet much of the genetic determinants underlying early neural dysfunction in AD remain…
AI Model Predicts New Uses for Existing Drugs Using Gene Data
Transcriptome-wide association studies (TWAS) can identify genes where genetically predicted gene expression is associated with disease risk, but translating those signals into therapeutic…