Medicine

Continuous or Fixed-Duration Maintenance Therapy in Multiple Myeloma

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This study compared continuous maintenance therapy versus fixed-duration maintenance therapy in patients with multiple myeloma following initial treatment response. The research examined progression-free survival, overall survival, and quality of life outcomes between the two treatment approaches. Results indicated differences in disease control and treatment burden between continuous and time-limited maintenance strategies.


The findings inform clinical decision-making regarding optimal maintenance therapy duration for multiple myeloma patients, balancing disease control against treatment-related toxicity and quality of life. This has direct implications for treatment guidelines and helps physicians and patients make more informed choices about long-term disease management.


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New England Journal of Medicine, Volume 395, Issue 3, Page 221-232, July 16, 2026.

Source: Continuous or Fixed-Duration Maintenance Therapy in Multiple Myeloma