Correction: Phytochemical profiling of Vitex negundo seeds via UHPLC-QTOF-MS/MS analyses with antimicrobial evaluation and in silico targeting of DNA Gyrase B and Secreted Aspartic Proteinase 2 (SAP2)

AI Insight

This article presents a phytochemical analysis of Vitex negundo seeds using Ultra-High Performance Liquid Chromatography coupled with Quadrupole Time-of-Flight Mass Spectrometry (UHPLC-QTOF-MS/MS) to identify and profile bioactive compounds. The study evaluates the antimicrobial properties of these seed extracts and employs in silico computational methods to assess the potential of identified compounds as inhibitors of two microbial targets: DNA Gyrase B, a bacterial enzyme involved in DNA replication, and Secreted Aspartic Proteinase 2 (SAP2), a virulence factor in fungal pathogens. Notably, this publication is a correction to an earlier article, meaning the findings presented have undergone a post-publication revision to address errors or inaccuracies in the original work.

Why it matters

Identifying plant-derived compounds with antimicrobial properties and validated molecular targets is relevant to the search for new therapeutic agents, particularly given the growing challenge of antimicrobial resistance. Vitex negundo has a history of use in traditional medicine, and rigorous chemical profiling combined with computational target validation may support the development of evidence-based natural product research.