Chemistry

Four ζ-carotene isomers reveal light-driven shifts and skin-protective potential

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BiosynthesisCarotenoidsPhotoisomerization

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Researchers have successfully isolated and purified four geometric isomers of ζ-carotene, a carotenoid intermediate in lycopene biosynthesis found in plants and photosynthetic organisms. This is the first systematic characterization of these isomers' distinct properties, including their spectral characteristics, photoisomerization behavior, UV-shielding capacity, and antioxidant activity. The study reveals isomer-specific differences in biological activities relevant to skin health and photoprotection.


The findings establish ζ-carotene as a promising natural ingredient for skincare and sun protection products. Understanding the specific properties of each isomer could enable targeted development of more effective photoprotective and antioxidant formulations for dermatological applications.


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ζ-Carotene, a key intermediate in lycopene biosynthesis, is widely found in plants and photosynthetic microorganisms, but its isomer-specific properties remain poorly understood due to isolation and purification challenges. Researchers have now developed a purification strategy to obtain high-purity geometric isomers and systematically characterized, for the first time, their isomer-specific spectral properties, photoisomerization behavior, UV-shielding capacity, antioxidant activity and skin-related biological activities—highlighting ζ-carotene’s promise as a natural ingredient for skin health and photoprotection.

Source: Four ζ-carotene isomers reveal light-driven shifts and skin-protective potential