AI Insight
The LatAm-FINGERS trial tested a culturally adapted multidomain lifestyle intervention in older Latin American adults at risk of cognitive decline through a single-blind, multicentre randomised controlled trial. Participants receiving the structured multidomain intervention showed greater cognitive improvements compared to those receiving flexible health advice. This study demonstrates that lifestyle interventions targeting multiple domains can be successfully implemented in Latin American populations and may help prevent cognitive decline.
Why it matters
This research extends dementia prevention evidence to Latin American populations, which have been historically underrepresented in cognitive decline research. The findings support the scalability of multidomain lifestyle interventions in low- and middle-income countries facing rapidly increasing dementia burdens, offering a practical prevention strategy that can be culturally adapted.
Understand the Science
A culturally adapted multidomain lifestyle intervention was feasible across Latin America and resulted in greater cognitive improvements than a flexible health-advice intervention in older adults at risk of cognitive decline. These findings extend the evidence base for multidomain lifestyle interventions to populations historically under-represented in dementia research, supporting their feasibility and scalability as strategies to reduce cognitive decline risk amid the rapidly growing burden of dementia in low-income and middle-income countries.