AI Insight
Researchers have identified an enzyme called phenolic phosphate synthetase (BsPPS) from Bacillus subtilis bacteria that can attach phosphate groups to various phenolic compounds found in plants. This enzymatic modification increases the water solubility of these natural compounds, which typically have poor solubility that limits their absorption in the body. A new fluorescent screening method enables rapid testing of thousands of enzyme variants to optimize this phosphorylation process.
Why it matters
The improved water solubility of modified plant compounds could enhance their bioavailability and effectiveness when used as nutraceuticals or therapeutic agents. This technology provides a faster way to engineer enzymes for producing more absorbable versions of beneficial natural compounds, potentially leading to improved dietary supplements and pharmaceutical applications.
Understand the Science
Many natural plant compounds have promising health-related properties, but their poor water solubility can limit how effectively they are absorbed and used. In previous work, researchers discovered an enzyme from Bacillus subtilis, called phenolic phosphate synthetase (BsPPS), that can attach phosphate groups to a broad range of phenolic compounds. This modification can help make these compounds more water-soluble and support the development of improved nutraceuticals and related products.
Source: Fluorescent test speeds screening of thousands of enzyme variants that modify plant compounds