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Yeast gametes sacrifice fitness to favor parent-specific gene expression

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This study investigates how differences between male and female gametes evolve by examining the meiotic cohesin protein Rec8 in fission yeast. Researchers found that Rec8 imposes fitness costs on gametes, creating selective pressure that favors parental bias in gene expression patterns. The findings provide empirical evidence for mechanisms underlying the evolutionary transition from equivalent gametes to distinct male and female reproductive cells.


This research addresses a fundamental question in evolutionary biology about how sexual dimorphism in reproduction originates at the cellular level. Understanding these mechanisms could inform broader questions about the evolution of sexual reproduction and the molecular basis for differences between egg and sperm cells across species.


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Proceedings of the National Academy of Sciences, Volume 123, Issue 27, July 2026. <br/>SignificanceThe emergence of distinct male and female gametes is a recurrent transition in the evolution of sexual reproduction, yet how differences between initially equivalent gametes first arise remains poorly understood beyond theoretical models. …

Source: Meiotic cohesin Rec8 imposes fitness costs on fission yeast gametes favoring the evolution of parental bias in gene expression