Chemistry

[ASAP] Nitrate-Driven Proton-Coupled Photoelectron Transfer Enables Cascade C–N Coupling of Lactic Acid to Alanine

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This study demonstrates a photocatalytic pathway in which nitrate acts as a nitrogen source to facilitate cascade carbon-nitrogen (C-N) coupling with lactic acid, ultimately producing alanine, a biologically important amino acid. The mechanism involves a proton-coupled photoelectron transfer process driven by nitrate, enabling the selective formation of the C-N bond under light irradiation. The research establishes a conceptual framework for converting simple organic acids and inorganic nitrogen species into value-added amino acids through a light-driven catalytic strategy.


This work offers a potential route for sustainable amino acid synthesis by utilizing nitrate, a widespread environmental pollutant, as a nitrogen feedstock, which could contribute to both green chemistry and nutrient recycling efforts. If scalable, this approach may reduce reliance on energy-intensive industrial processes for amino acid production.


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Journal of the American Chemical Society
DOI: 10.1021/jacs.6c07088

Source: [ASAP] Nitrate-Driven Proton-Coupled Photoelectron Transfer Enables Cascade C–N Coupling of Lactic Acid to Alanine