Animals facing threat must integrate multiple streams of information – about danger, environment, and internal state – into a time-pressured escape decision. In mice, this computation is performed by…
While coding regions in the genome have a direct interpretation in terms of protein products, significant fractions are non-coding and yet control essential biological functions. Unlike the genetic…
Circadian (~24 h) rhythms are essential for the survival of most organisms, as they optimize physiology and behavior with the time of day. They are defined by three fundamental properties: they are…
Background. Wildland firefighters experience repeated occupational exposure to wildfire smoke at high particulate matter (PM) concentrations, leading to elevated cardiovascular disease risk and…
Cleptoparasitism, or brood parasitism, is a striking behavioral strategy observed in approximately 13% of all bee species, yet its genomic underpinnings remain largely unexplored. We present the…
Incomplete letter recognition tasks are frequently used to detect visual deficits arising from neurodegenerative syndromes, including Posterior Cortical Atrophy (PCA; ‘visual-variant Alzheimer’s…
Abstract: Metabolic-associated steatotic liver disease (MASLD) is a prevalent liver disease driven by complex dysregulation of hepatic lipid metabolism. Here we show that copper deficiency is a…
BRCA-deficient high-grade serous ovarian cancer is characterized by profound genomic instability and elevated replication-associated DNA damage, rendering these tumors initially sensitive to…
To explore conserved mechanisms and functions across mechanosensory kinases associated with the skeletal architectures of the cell, we investigated in vitro and in vivo the substrate targeting of…
The ability to encode and reliably read nanoscale information is increasingly important for multiplexed biomolecular detection and super-resolution imaging. DNA origami provides a uniquely…