Urinary tract infections (UTIs) are the most prevalent bacterial infections globally, and their management increasingly challenged by antimicrobial resistance (AMR). Probiotics offer a promising…
Upon infecting a bacterium, temperate phages must decide between killing the cell to reproduce (lysis) or entering a symbiotic lifestyle (lysogeny). This choice is often informed by the cell’s state,…
When cells enter S phase, bidirectional DNA replication is initiated through the kinase-regulated recruitment of three activators (Cdc45, GINS and Pol epsilon) to a duplex DNA-loaded double hexamer…
Chemotherapeutic treatment of breast cancer with Doxorubicin (DOX) can induce tumor and stromal cell senescence leading to therapy-resistance. Senescence-associated secretory phenotype (SASP)…
Background: Obesity significantly increases the risk of prognosis and clinical outcomes in pancreatic ductal adenocarcinoma (PDAC). While research on the interactions between obesity and the tumor…
How neural structure constrains cortical dynamics and perceptual experience remains a fundamental open question. The MICrONS connectomics dataset enables direct examination of this problem by…
Aim. Maternal iron deficiency (ID) during pregnancy induces cardiovascular adaptations, including reduced blood pressure and improved cardiac efficiency in hypertensive pregnancy. Iron is essential…
Inside the California NanoSystems Institute at UCLA, where some of the most advanced and technical automated infrastructure on campus resides, two students saw an opportunity hiding in plain sight.
Peptide mapping is a critical tool for characterizing biotherapeutic proteins and is essential for the development of monoclonal antibody drugs. Here we describe a new direct infusion technology that…
Researchers at the International Institute of Molecular and Cell Biology in Warsaw (IIMCB), led by Prof. Gracjan Michlewski, have shown that a subtle difference at the very beginning of an RNA…