Physics

Single-shot microneedle-encoded upconversion lifetime mapping for real-time in vivo thermo-dermoscopy

AI Insight

Researchers developed a microneedle-based sensor system that integrates upconversion nanoparticles capable of encoding temperature information through luminescence lifetime mapping in a single imaging acquisition. The device enables real-time, minimally invasive dermal thermometry by translating temperature-dependent photoluminescence decay times into spatially resolved thermal maps of subsurface skin tissue. This approach, termed thermo-dermoscopy, overcomes limitations of conventional surface infrared thermography by accessing deeper dermal layers with improved spatial and temporal resolution.


This technology could enable continuous, non-destructive skin temperature monitoring with clinical applications in early detection of inflammatory conditions, tumor margin assessment, and wound healing evaluation. The single-shot acquisition design reduces motion artifacts and makes the platform practical for point-of-care deployment.


Source: Single-shot microneedle-encoded upconversion lifetime mapping for real-time in vivo thermo-dermoscopy