Cholestatic and autoimmune liver diseases, bile duct injury, oxidative stress, and therapeutic strategies
Abstract Cholestatic and autoimmune liver diseases, including primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC), and intrahepatic cholestasis of pregnancy (ICP), represent a heterogeneous group of conditions characterized by impaired bile flow, bile duct injury, and progressive hepatobiliary dysfunction. Oxidative stress has emerged as a critical factor linking bile acid toxicity to inflammation, fibrosis, and … Read more