Iconic Sound-Shape Correspondences in Aphasia
Purpose: To examine speech iconicity for shape in aphasia, we compared iconicity ratings from people with aphasia to those from neurologically intact individuals and evaluated how iconicity relates…
Biology
Error-driven representation learning in the mesolimbic system
In reinforcement learning, an agent learns to map representations of the environment state to predictions of future reward. Most prior work in neuroscience has assumed a fixed representation and…
Reduced MOV10 reveals novel functional cortical connections in an increased fear response
The RNA helicase MOV10 is highly expressed in developing brain, is present in synapses and is required for embryonic viability. A murine brain-specific knockout of MOV10 (Mov10 Deletion) has a…
Reduced cortical VPS26B levels are associated with altered glutamate receptor expression and synaptic protein loss in the primary motor cortex of a Parkinsonian mouse model
Parkinsons disease (PD) is associated with motor impairment and cortical synaptic dysfunction, which involve altered glutamate receptor trafficking, yet the underlying mechanisms remain incompletely…
ToxCastLite: A portable semantic evidence graph linking in vitro bioactivity, in vivo toxicity, and exposure-use context
Motivation: The ToxCast database is a valuable resource for computational toxicology and new approach methodologies (NAMs), but the approximately 100GB MySQL distribution is difficult to use for…
Emotional valence of conspecific vocalizations modulates auditory and limbic brain activity in juvenile pigs
Pig vocalizations convey information about the emotional states of individuals, varying with arousal and valence. Studies show that different call types reflect distinct emotional contexts and social…
CDK12 and CDK13 suppress distinct intronic polyadenylation sites
Cyclin-dependent kinases CDK12 and CDK13 are RNA polymerase II C-terminal domain Ser2 kinases that regulate transcriptional elongation and co-transcriptional RNA processing. Loss-of-function (LOF)…
BioGAIP: A Scalable, User-Friendly and Robust LLM-Powered Multi-Agent System for Automated Bioinformatics Tasks
The rapid explosion of large-scale, high-throughput biological data has created an urgent demand for efficient analysis pipelines. Traditional bioinformatics approaches, while powerful, often require…
Cooperative regulation of NF-E2 related factor 1 protein stability and transcriptional activation by endoplasmic reticulum-associated degradation system mediator, Selenoprotein S/K.
NRF1 is a key mediator of the proteasome recovery pathway, yet its regulation by ER-resident factors is not fully elucidated. Here, we demonstrate that selenoproteins SELS and SELK are critical…
Geometric averaging provides normalization-invariant feature ranking in compositional sequencing data
In compositional next-generation sequencing (NGS) analyses (including microbiome studies, RNA-seq and metagenomics) the arithmetic mean (AM) of relative proportions is the default operator for…