Phylogenetic network inference methods are increasingly used to detect hybridization and gene flow from genomic data, but their robustness to common sources of model violation remains poorly…
For over four decades, the bivalve Anomalocardia flexuosa has been recorded in Hong Kong coastal waters. However, the known native distribution of this heavily exploited commercial species is…
Background and Objectives: Intravesical gemcitabine/docetaxel (Gem/Doce) is an effective therapy for Bacillus Calmette-Guerin (BCG)-unresponsive non-muscle-invasive bladder cancer (NMIBC), achieving…
Background As pangenomes approach saturation, identifying additional genomes that contribute novel sequence information becomes increasingly difficult. Current sample-selection strategies often rely…
The advancement of deep generative models has facilitated de novo protein and antibody design, yet translation to experimental success is hindered by a high generation rate of structural decoys….
Multimodal protein language models have transformed protein design, yet their capacity to capture complex topological features remains poorly understood. We use knotted proteins, rare structures in…
Severe salivary gland injury can cause chronic xerostomia and persistent secretory dysfunction, yet the epithelial populations that support repair remain poorly defined. Here, we identify NGFR/Ngfr…
In plants, effector-triggered immunity (ETI) is initiated when NLR receptors recognize pathogen effectors, yet the molecular signals linking this recognition to downstream defense activation remain…
While tree pollen is a major trigger of allergic respiratory conditions and different taxa exhibit varying allergenic potentials, the lack of high-resolution, taxon-specific exposure metrics have…
How combinatorial cell signaling controls cellular decisions in the face of crosstalk is a fundamental problem in biology. A key open question is whether a single snapshot of signaling is sufficient…