Background High Intensity Use of urgent medical services by patients is widely recognised in urgent and emergency care. Studies of high intensity use of the emergency department have consistently…
Lipoprotein(a) (Lp(a)) is associated with atherothrombosis through several mechanisms, including putative antifibrinolytic properties. In the ASPREE randomized trial of daily low-dose aspirin for…
Introduction Cutaneous leishmaniasis (CL) is a neglected tropical disease associated with reduced health-related quality of life (HRQoL) that leads to permanent scars, anatomical damage and…
Background: Lipoprotein(a) (Lp[a]) is a genetically determined causal and independent cardiovascular risk factor and Lp(a) targeted therapies are being developed. However, evidence on the safety of…
Background: Atrial high-rate episodes (AHRE) detected by cardiac implantable electronic devices (CIEDs) are associated with increased thromboembolic risk, yet their clinical significance and optimal…
Mental illness poses a substantial global burden, yet existing psychotherapies and psychopharmacologies often produce limited outcomes. Psychedelic assisted therapies have emerged as potential…
Background: U.S. POINTER reported a modest structured-versus-self-guided difference in the annual rate of global cognitive change. However, the clinical and economic implications of this incremental…
Background: Midurethral sling placement is often performed during prolapse repair to treat or prevent stress urinary incontinence. However, some women experience persistent or new-onset stress or…
Objective. Pathological beta oscillations are a hallmark of Parkinson’s Disease (PD) and are linked with symptom severity and therapeutic efficacy of deep brain stimulation (DBS). Although some…
Background: Heterogeneity in symptom presentation and treatment response in irritable bowel syndrome (IBS) remains poorly understood. The gut microbiota may contribute to this variability, but its…