What Do We Know About RNA Therapeutics and Drug Delivery? A Science-Based Overview In December 2023, researchers announced a breakthrough that would have seemed like science fiction a decade ago: a therapy based entirely on RNA successfully treated a patient with a previously incurable genetic disorder. This wasn’t a one-off miracle cure, but rather the … Read more
The CARDIO-TTRansform trial investigating eplontersen in patients with transthyretin-mediated amyloid cardiomyopathy did not meet its primary efficacy endpoint, according to results presented in a…
Oral anticoagulant therapy lowered the risk of adverse clinical events compared with no anticoagulation in patients with atrial fibrillation at intermediate stroke risk, according to results from the…
Chronic kidney disease (CKD) is a major health burden affecting approximately one in 10 adults globally. Even with improved treatments, many patients continue to experience worsening kidney function,…
Adolescence is a critical time for nutritional health, given the rapid physical growth, hormonal changes and neurodevelopmental shifts taking place. Yet diet quality is at its lowest during this…
In a tale of identities as divergent as “The Prince and the Pauper,” a well-known cancer-causing gene also influences cells in a zombie-like state meant to prevent cancer.
Allograft survival is unaffected when kidney transplant (KT) is performed after a short-term pretransplant dialysis duration (PTDD), according to a study published online Aug. 24 in the International…
A single dose of Kylo-11 was well tolerated, and at doses of 225 mg or higher, durably reduced serum lipoprotein(a) concentrations up to 48 weeks.
Lipoprotein(a) is causally associated with an increased risk of atherosclerotic cardiovascular disease and calcific aortic valve stenosis.1 Clinical trials of proprotein convertase subtilisin/kexin…
Scientists have created light-activated drugs that helped blind mice perceive light again and restored visually guided behavior without gene therapy, implants, or specialized lighting. Even more…