SCN2A-related disorders result from pathogenic variants in the gene encoding for the voltage-gated sodium channel Nav1.2. Collectively, these disorders result in variable age of onset epilepsy,…
The lateral prefrontal cortex (LPFC) actively contributes to the adaptive control of goal-directed behavior. Evidence suggests that the LPFC encodes the behavioral relevance of stimuli,…
Mammals rely on their senses to establish their position in space. Neural activity in the hippocampus maps position, yet how sensory signals reach the hippocampus remains poorly understood. Here we…
Long-term potentiation (LTP) is a key cellular mechanism underlying learning and memory, but its conservation across species remains unclear. Using nonhuman primates (NHPs), we examined hippocampal…
Lesion network mapping (LNM) and its derivatives successfully integrate anatomically distributed brain loci into common symptom-associated functional networks, however, their statistical validity and…
Anhedonia-the diminished capacity to experience or anticipate pleasure-is among the most common consequences of early-life unpredictability, yet how these co-occurring conditions jointly shape…
Purpose: To examine speech iconicity for shape in aphasia, we compared iconicity ratings from people with aphasia to those from neurologically intact individuals and evaluated how iconicity relates…
In reinforcement learning, an agent learns to map representations of the environment state to predictions of future reward. Most prior work in neuroscience has assumed a fixed representation and…
The RNA helicase MOV10 is highly expressed in developing brain, is present in synapses and is required for embryonic viability. A murine brain-specific knockout of MOV10 (Mov10 Deletion) has a…
Parkinsons disease (PD) is associated with motor impairment and cortical synaptic dysfunction, which involve altered glutamate receptor trafficking, yet the underlying mechanisms remain incompletely…