Nature Neuroscience, Published online: 09 December 2025; doi:10.1038/s41593-025-02112-z Epitranscriptomic (m6A) profiling across five human brain regions and developmental stages uncovers region-specific and age-specific dynamics, preferential enrichment in disease-associated genes, and colocalization with disease risk loci.
Nature Neuroscience, Published online: 08 December 2025; doi:10.1038/s41593-025-02128-5 Reproducible cortical firing patterns arise from hierarchical modular networks shaped by distance-dependent connectivity rather than attractor dynamics, suggesting that cortex is prewired for scaffold coordination and learning.
Nature Neuroscience, Published online: 08 December 2025; doi:10.1038/s41593-025-02127-6 This work presents a fully implantable wireless optogenetic device that delivers spatiotemporally patterned cortical stimulation through the skull and generates artificial perception in mice.
Image credit: Denis Pobytov / DigitalVision Vectors / Getty Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have revolutionized the treatment of obesity and type 2 diabetes. Medicines such as semaglutide (Ozempic and Wegovy) and tirzepatide (Mounjaro/Zepbound) are remarkably effective at inducing substantial weight loss and improving markers of metabolic health. In addition to their metabolic effects, these … Read more
Abstract STEER (NCT05089656) was a 52-week, phase 3, multicenter, randomized, sham-controlled, double-blind trial evaluating intrathecal onasemnogene abeparvovec (OAV101 IT), a one-time gene transfer therapy, in patients with spinal muscular atrophy (SMA). Participants ranged in age from 2 years to <18 years, were treatment-naive and were able to sit but never walked independently. Primary efficacy endpoint was change … Read more
Abstract Intrathecal onasemnogene abeparvovec (OAV101 IT) may enable a one-time gene transfer therapy, addressing an unmet need across the broader spinal muscular atrophy (SMA) population. STRENGTH (NCT05386680) was a 52-week, phase 3b, single-arm, open-label, multicenter study evaluating OAV101 IT in participants with SMA aged 2 to <18 years who discontinued nusinersen or risdiplam. The primary objective … Read more
A full‑lifecycle clock derived from millions of routine clinical records reveals that human development and aging form a continuous physiological trajectory, enabling early disease detection and mechanistic insights for preventive and precision health. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution Access options Access through … Read more
Nature Neuroscience, Published online: 05 December 2025; doi:10.1038/s41593-025-02135-6 Hesitation—pausing in the face of uncertainty—is ubiquitous in daily life and disrupted in several psychiatric disorders. Unlike other forms of response inhibition, hesitation is mediated by indirect, but not direct, pathway striatal neurons.
Addendum to: Nature Medicine https://doi.org/10.1038/nm.2090, published online 24 January 2010. The Editors would like to alert readers that a concern has been raised regarding the similarity of Fig. 2d Cisplat+ pr-cas3 blots representing MDA231 and BT549 cells. These blots appear to share some highly similar features; however, due to the age of the article and … Read more
Nature Neuroscience, Published online: 04 December 2025; doi:10.1038/s41593-025-02151-6 De la Rosa et al. developed an in vivo CRISPR screening system to dissect macrophage regulation in multiple sclerosis models, revealing key cytokine signaling pathways that control myeloid cell behavior in neuroinflammation.